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The Davies
Laboratory
THE TEAM
Meet the team
PRINCIPAL INVESTIGATOR
Dr Clare Davies
PhD, B.Med.Sc
Reader in Cancer Cell Biology
I completed my PhD in Cancer Studies at the University of Birmingham, UK, and have ever since been interested in understanding how post-translational modification of proteins contributes to malignant progression. I first came across arginine methylation during my post-doctoral position at the CRUK-London Research Institute (now The Crick) in the lab of Dr. Axel Behrens studying c-Jun-mediated gene expression, and then moved to The University of Manchester to work with Dr. Cathy Tournier on mouse models of breast, skin and pancreatic cancer. I was awarded a Birmingham Fellow in 2012 to start my own research group at the Institute of Cancer and Genomic Sciences and was promoted to Reader in 2019. I really enjoy mentoring the younger members of the team, and in my spare time can be found in the gym sweating and singing along to a Les Mills class, hiking up a mountain, or planning my next big travel tip abroad. Dogs are by far my favourite animal.
POSTDOCTORAL RESEARCHERS
Dr Kelly Chiang
PhD, BSc
After completing a PhD at the Paterson Institute for Cancer Research in Manchester, I moved to the University of Glasgow to begin my foray into the infinite world of epigenetics. I continued this journey after moving to the University of Birmingham where I currently work on the role of arginine methylation in the regulation of breast cancer stem cells, which has also allowed me to dabble part-time in bioinformatics. Outside the lab, I prefer science of a different nature - one which usually results in a more tasty endpoint than pouring an SDS-PAGE gel.
Dr Soo Youn Choi
PhD, MSc
I obtained my MSc in Genetic Engineering and PhD in Biochemistry from Seoul National University in South Korea. After my first postdoctoral training in MRC-PPU (MRC -Protein Phosphorylation and Ubiquitination Unit, University of Dundee), I joined the lab to conduct research focusing on the functions of PRMT5 in breast cancer. I like all kinds of art form, love visiting art galleries and theatres. Actually that is why I like science most as it is like a journey to understand the art of nature.
Dr Gemma Regan-Mochrie
I obtained my PhD in Cancer Biology from Memorial Sloan Kettering Cancer Center in New York City. I was fascinated by DNA replication and I studied both the role of sumoylation of the origin recognition complex and a conserved domain on the leading strand polymerase. I joined the Davies lab to pursue my interest in post-translational modifications and study the role of PRMT5 in breast cancer. Outside of the lab I love to cook, hike and travel. I also have a wonderful cat named Freyja.
RESEARCH TECHNICIANS
Ciara Ward
Research Technician
I completed a Masters of Research in Cancer Sciences at the University of Birmingham before I joined the Davies lab as a research technician in October 2021. In my spare time I love to read and am often found with my head in stranger worlds. I also adore travelling and I am hoping to visit new places soon!
PhD STUDENTS
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Lizzie Dufficy
iCASE Astra Zeneca BBSRC Studentship
I obtained my Cancer Sciences M.Res. in the Davies Lab before moving on to a Wellcome Trust funded Research Assistant position at Cambridge University. Following this I had the opportunity to return to the Davies Lab to undertake a PhD. My research interests include molecular mechanisms involved in the DNA damage response, the arginine methyltransferase PRMT5 and breast cancer. Outside of work I love to paint and am a keen runner. Last year I ran The Great North Run to raise money for Alzheimers Society. Dogs are also my favourite animal!
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Karan Sharma
CRUK PhD Studentship
I studied Biomedical Science at King's College London as an undergraduate. In order to further my interest in cancer research I chose to do a MSc at the University of Leicester in the Molecular Pathology and Therapeutics of Cancer. I joined The Davies Lab in 2019 as a Research Technician, and I started my PhD in October 2021. My research within The Davies Lab focuses on FXR1 and the DNA damage response. In my spare time I love watching and playing cricket. I also like music and most art forms.
Nicole Mcfadzean
MIBTP BBSRC PhD Studentship
I studied Veterinary Biosciences at the University of Glasgow as an undergraduate. I then worked as a research assistant on a Humanimal Trust project aiming to develop a test that could diagnose and monitor cancers through circulating tumour DNA. My PhD included a training year to learn statistics and bioinformatics skills and my research within the Davies Lab focuses on investigating the recruitment of PRMTs to sites of DNA damage and the roles of histone arginine methylation within the DNA damage response. In my spare time I enjoy listening to and playing music as well as meeting up with friends.
MRes/MSci/Intercalcating medical STUDENTS
Chowmia
Muraleetharan
Paige Shaw
I’m a MSci Biochemistry student at the University of Birmingham, with an interest towards mechanisms within cancer. My project is based on PRMT5 dependent splicing in breast cancer stem cells. In my spare time I enjoy going to the gym, reading and binge-watching foreign TV shows
Whilst completing my biology undergraduate degree at the University of Birmingham, I gained a particular interest in cancer and decided to pursue this interest by studying an MRes in Cancer Sciences also at the University of Birmingham. The project I’m working on in the Davies lab is investigating the effects of citrullination – a post-translational modification – on DNA damage response pathways. In my spare time, I really enjoy going to salsa classes, watching Formula 1, and letting my creative side free, which often includes designing posters, and making jewellery.
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Charlie Brockwell
I am a student at the University of Birmingham who has taken a year to intercalate in the Cancer stream of Clinical Sciences, after my 3rd year of reading Medicine. In my project, am investigating targeting EWS-FLI driven Ewing Sarcoma. I am keen to further develop my interest in oncology and cancer research. Outside of my studies I love playing hockey, travelling and I also enjoy my role as the President of this university's MedSoc.
Dr Debashish Sahay
PhD
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